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DOI:10.1016/j.jpsychires.2018.12.014 - Corpus ID: 58601994
@article{Sarris2019LtheanineIT, title={L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.}, author={Jerome Sarris and Gerard J. Byrne and Lachlan Cribb and Georgina Oliver and Jenifer A Murphy and Patricia Macdonald and Sonia Nazareth and Diana Karamacoska and Samantha Galea and Anika Short and Carolyn C Ee and Yoann Birling and Ranjit Menon and Chee H. Ng}, journal={Journal of psychiatric research}, year={2019}, volume={110}, pages={ 31-37 }, url={https://api.semanticscholar.org/CorpusID:58601994}}
- J. Sarris, G. Byrne, C. Ng
- Published in Journal of Psychiatric… 1 March 2019
- Medicine
31 Citations
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It is suggested that supplementation of 200–400mg/day of L-THE may assist in the reduction of stress and anxiety in people exposed to stressful conditions.
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- V. BorgonettiP. GovernaM. BiagiN. Galeotti
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TMM showed an anxiolytic-like and antidepressant-like activity in vivo, which was related to a neuroprotective effect in an in vitro model of excitotoxicity, suggesting a non-benzodiazepine-like mechanism of action.
- 12 [PDF]
- T. DassanayakeC. KahathuduwaV. Weerasinghe
- 2020
Medicine
Nutritional neuroscience
The findings indicate L-theanine can increase attentional processing of auditory information in a dose-dependent manner, and the linear dose–response attentional effects observed warrant further studies with higher doses of L- theanine.
- 4
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Background: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by tics and co-occurring disorders. It has been suggested that anxiety occurs in 2–45% patients affected by Tourette…
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- Highly Influenced[PDF]
- M. EvansAlison C. McDonaldLora XiongDavid C. CrowleyN. Guthrie
- 2021
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A single dose of AlphaWave®l-Theanine significantly increased frontal region alpha power compared to placebo in response to an acute stress challenge and was found to be safe and well tolerated by participants.
- 5
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- A. CastroM. Gili Miquel Roca
- 2023
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Nutrients
The high and regular consumption of carbonated/soft drink with sugar tended to be associated with higher level of anxiety in a multicountry sample of overweight subjects with subsyndromal depressive symptoms.
- Monique AucoinL. Lachance K. Cooley
- 2021
Medicine, Agricultural and Food Sciences
Nutrients
This scoping review sought to systematically map the existing literature on anxiety disorders and nutrition in order to identify associations between dietary factors and anxiety symptoms or disorder prevalence as well as identify gaps and opportunities for further research.
- 58 [PDF]
- Silan WuJiahui Li Huabin Li
- 2022
Medicine, Agricultural and Food Sciences
Antioxidants
This narrative review, which summarized the most recent advancements regarding the effects of dietary natural products and nutrients on depression and anxiety, and their underlying mechanisms are discussed, hopes that this paper can provide a better understanding of the anti-depressive and anxiolytic action of dietarynatural products.
- 13 [PDF]
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L-theanine augmentation of antipsychotic therapy can ameliorate positive, activation, and anxiety symptoms in schizophrenia and schizoaffective disorder patients.
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Since sleep problems are a common co-morbidity associated with ADHD, and because disturbed sleep may be linked etiologically to this disorder, L-theanine may represent a safe and important adjunctive therapy in childhood ADHD.
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It is suggested that while L‐ theanine may have some relaxing effects under resting conditions, neither L‐theanine not alprazolam demonstrate any acute anxiolytic effects under conditions of increased anxiety in the AA model.
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The MRS findings suggest that l-theanine stabilises the glutamatergic concentration in the brain, which is a possible mechanism underlying the therapeutic effect of l- theanine in schizophrenia.
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Based on the evidence available to us, it is recommended that along with the ADs, benzodiazepines be considered a possible first-line therapy in eligible patients based on the discretion and clinical judgment of the treating physician.
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